Haemophilia
Ummahan, Nina, Magnus and Karoline.
Haemophilia is a group of hereditary genetic disorders that impair the body’s ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. A person with haemophilia does not bleed more extremely than a person without, but can bleed for much longer time.
Haemophilia is more likely to occur in males than females, and that’s because it’s a recessive sex-linked, X-chromosome disorder. The reason that it isn’t likely for females to have this illness is because women have two X-chromosomes, while men have only one. The defective gene is guaranteed to reveal in any male who carries it. A female must receive two defective X-chromosome to be carrier of the disease. She has to have one chromosome from her mother and the other one from her father, who must therefore be a haemophiliac himself.
There are in Denmark 445 people suffering from the haemophilia and in Iceland there are 55 people living with the disease.
Haemophilia is more likely to occur in males than females, and that’s because it’s a recessive sex-linked, X-chromosome disorder. The reason that it isn’t likely for females to have this illness is because women have two X-chromosomes, while men have only one. The defective gene is guaranteed to reveal in any male who carries it. A female must receive two defective X-chromosome to be carrier of the disease. She has to have one chromosome from her mother and the other one from her father, who must therefore be a haemophiliac himself.
There are in Denmark 445 people suffering from the haemophilia and in Iceland there are 55 people living with the disease.
Queen Victoria was a career of haemophilia. None of Victoria’s parents had the disease and therefore she generated a mutation for haemophilia. She passed it on to her son Leopold, which you can see on the genealogical tree above. She gave it on to some of her daughters(the half red circles in 3. Generation) as well, who didn’t suffered from the illness, but passed it on to there children. Because of that we can conclude that haemophilia is a recessive disease. As you can see on the genealogical tree the only ones who suffered from haemophilia were males (marked as a red squire). It support the general way that sex-linked diseases affect one gender more than the other.